The four remaining fourth-round clashes will take place at Roland Garros on Monday, with Stefanos Tsitsipas aiming to reach the quarter-finals for a third consecutive year.
World number 2 Daniil Medvedev is on night duty against Marin Cilic, while Casper Ruud and Hubert Hurkacz will meet for the first time. #NextGenATP stars Holger Rune and Jannik Sinner will be looking to continue their runs when they take on Tsitsipas and Andrey Rublev respectively.
In doubles, two teams will reserve their place in the semi-finals.
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 Stefanos Tsitsipas (GRE) against Holger Rune (DEN)
Tsitsipas is set to face his toughest test yet in Paris when he takes on #NextGenATP Dane Rune for the first time on the Philippe Chatrier court.
After reaching the final at Roland Garros last year, the Greek is aiming to go even further in the French capital this week. After being forced to work hard in his first two matches against Italian #NextGenATP Lorenzo Musetti and Czech qualifier Zdenek Kolar, the world No. 5 put in his best performance of the week against Sweden’s Mikael Ymer.
“It’s good to have a game like this once in a while,” Tsitsipas said after his win over Ymer. “Especially when you go in, when you go into a game with so much confidence and you believe that you can really structure your tactics and you feel the confidence in your game itself, having built over previous games.
“Having played a lot of rallies but having been in a lot of situations in a match, you are able to lift the spirit a bit and see the best opportunities and possibilities for yourself.”
Case over ✅@steftsitsipas eliminates Ymer 6-2, 6-2, 6-1 to clinch a place in the final 16 in Paris! 🔥@Roland Garros | #Roland Garros pic.twitter.com/eJLMZr7ZLX
– ATP Tour (@atptour) May 28, 2022
The 23-year-old will have to find his A-game if he wants to overthrow Rune, with the 19-year-old entering the game with great confidence. The Dane is yet to drop a set on his Paris debut, moving up to No. 31 in the Pepperstone ATP Live rankings.
Rune clinched his first ATP Tour title in Munich last month and is 13-6 on clay this season at tour-level events. Meanwhile, Tsitsipas has won 34 tour-leading victories in 2022 and is aiming to claim his second title of the season in Paris, having retained his crown in Monte Carlo.
 Daniil Medvedev vs.  Marin Cilic (CRO)
World No. 2 Daniil Medvedev arrived at Roland Garros with just one clay-court game in store this season. However, he quickly found his lineup in the French capital, entering week two without dropping a set.
The 26-year-old, who lost to Richard Gasquet in Geneva in his first clay outing this year, swept Miomir Kecmanovic in straight sets in a performance so dominant it even surprised Medvedev.
“[It] was a great game against a tough opponent. To be honest, before the game I never thought I could make this score on clay,” Medvedev said. “Everything I wanted to do today worked. I served very well. I feel like I put almost all the returns.
Medvedev is in the running to take over the top spot in the Pepperstone ATP rankings from Novak Djokovic. He can return to No.1 on June 13 with a second-place finish in Paris, even if Djokovic lifts the trophy.
Croatian Marin Cilic, who is yet to beat the second seed in his previous three encounters, stands in the way of the 13-time tour-level starter for a second straight quarter-final in Paris.
Cilic defeated Gilles Simon to end the Frenchman’s final run at Roland Garros. The 33-year-old will be aiming for the quarter-finals in Paris for the third time, but the first since 2018 when he faced Medvedev in the night session at the Philippe Chatrier court.
 Andrei Rublev vs.  Jannik Sinner (ITA)
Fierce ball-striking will be the order of the day when Andrey Rublev and Jannik Sinner square off on Suzanne Lenglen Court.
It will be the third time they have met on clay and the second time this season, with Sinner currently holding bragging rights after beating the world No.7 in Barcelona last year and then in three sets in Monte Carlo. in April.
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Despite a leg injury against Mackenzie McDonald, the Italian reached the fourth round in Paris for the third consecutive year with a victory over the American. Sinner, who has only ever lost to 13-time Roland Garros champion Rafael Nadal at the Slam on clay, is aiming to reach the quarter-finals in a tour-level event for the fifth time this season.
Rublev edged out Cristian Garin to claim his third consecutive win in four opening week sets. The 2020 quarter-finalist clinched the third clay-court title of his career by beating Novak Djokovic to triumph in Belgrade in April.
 Casper Ruud (NOR) against Hubert Hurkacz  (POL)
Ruud made history by overtaking Lorenzo Sonego to become the first Norwegian to reach the fourth round at Roland Garros. However, the eighth seed will not yet be satisfied with what he has achieved as he targets further success on what many consider his best surface.
The 23-year-old has won seven of his eight ATP Tour titles on clay, with his last crown coming in Geneva just eight days ago. Ruud has now won his last seven games and will be looking to extend that run when he takes on world number 13 Hurkacz for the first time.
The love story with Paris continues 🧡@CasperRuud98 outlasts Lorenzo Sonego 6-2, 6-7(3), 1-6, 6-4, 6-3 to reach the last 16 for the first time.#Roland Garros pic.twitter.com/cxPDLkoNs3
— Roland Garros (@rolandgarros) May 28, 2022
Prior to this year, the Pole had qualified for the second round just once in four matches in the French capital. However, this week the 25-year-old showed the form that propelled him to the quarter-finals at the ATP Masters 1000 events in Monte Carlo and Madrid.
Backed by a solid serve, Hurkacz dispatched Italian #NextGenATP Giulio Zeppieri, Marco Cecchinato and David Goffin in straight sets.
The first two doubles quarter-finals are on Monday, with 16th seeds Rohan Bopanna and Matwe Middelkoop taking on Lloyd Glasspool and Harri Heliovaara. Bopanna and Middelkoop are competing together for the fourth time this season and upset second seeds Nikola Mektic and Mate Pavic in the third round.
The other clash will see Marcelo Arevalo and Jean-Julien Rojer take on Rafael Matos and David Vega Hernandez. Arevalo and Rojer have won titles together in Dallas and Delray Beach this season.